大豆异黄酮对异丙肾上腺素诱导大鼠心肌纤维化的保护作用

目的观察大豆异黄酮(Soybean isoflavone,SI)对异丙肾上腺素(Isoproterenol,ISO)诱导的心肌纤维化(Myocardial fibrosis,MF)的保护作用.方法异丙肾上腺素皮下注射诱导心肌纤维化模型,经SI低、中、高(30,60,120 mg/kg)3个剂量组和阳性对照卡托普利组(50 mg/kg)治疗后,观察其对心肌细胞直径(MD)、心室重量指数(HW/BW)、左心室重量指数(LVI)、羟脯氨酸(Hyp)含量及心肌组织中钙调神经磷酸酶(Calcineurin,Ca N)活性的影响.结果 SI不同剂量组均能够降低HW/BW和LVI(P0.05或P0.01),减少羟脯氨酸含量(P0.05或P0.01)),减小心肌细胞直径(P0.05或P0.01),降低心肌组织中Ca N的活性(P0.01),减轻ISO诱导的心肌纤维化.结论 SI对心肌纤维化的保护作用可能与降低心肌组织中钙调神经磷酸酶活性有关.     

基于改进型锁相环的单相并网逆变器

单相并网逆变器广泛地应用在新能源发电领域,它的一个关键技术就是对电网电压的锁相。分析了基于Park变换的锁相环原理,并进行了改进。针对并网逆变器采用的LCL滤波器,采用了基于电容电流前馈的有源阻尼控制方案,推导了LCL滤波器的模型,在此基础上加入电容电流前馈,推导出加入前馈后的数学模型,给出了不同前馈系数的bode图,分析出不同前馈系数的变化趋势。通过单相并网逆变器的仿真实验,验证了改进型锁相环和有源阻尼控制的正确性。搭建了硬件平台,进行了并网硬件实验,验证了以上理论的正确性和可行性。     

高凝油田不同驱替温度下孔渗变化规律及对相渗曲线特征参数的影响研究

高凝油藏(原油凝固点在40℃以上,含蜡量高的油藏)在开采过程中,由于黏度增加、析蜡等现象,将使得储层流动性变差,影响开发效果,但目前国内外针对高凝油的流变性及驱替过程中的储层物性变化规律的定性研究较少。根据海外某高凝油田A的流变性试验和驱替试验结果,分析了高凝油随温度降低所产生的黏度增加以及蜡的析出对孔隙度、渗透率和驱替效果的影响。重点分析了黏度、孔隙度、渗透率随温度变化的规律,并提出一项新的、可同时表征储层物性与流体性质的储层特征参数γ。分析了不同温度、不同γ下的相渗参数及相关关系。研究结果对类似高凝油田开发具有一定的参考意义。     

YPO4:Gd,Eu荧光粉的制备和发光性能研究

针对高温固相法的不足,采用高温固相法经两次煅烧合成了Eu3+激发Gd3+敏化的YPO4∶Gd,Eu荧光粉,一次煅烧和二次煅烧温度、时间分别为800℃,6 h和600℃,6 h时发光效果较好。采用XRD、SEM、荧光分光光度计对荧光粉的相结构、晶粒形貌、光致发光性能等进行了表征。结果表明,在800℃保温6 h获得的化合物XRD结果与标准卡片物质一致,但颗粒尺寸分布宽、形貌杂乱。经研磨后在600℃二次煅烧6 h,晶粒表面变得平整光滑,形貌呈现较规则的多面体结构。荧光分光光度计结果发现二次煅烧及掺杂敏化剂Gd都能明显提高材料的发光强度。     

稀土镝-槲皮素配合物的合成及光谱分析

根据配位化学及中药学的研究理论,结合槲皮素稀土配合物的结构特点,将槲皮素与稀土Dy3＋离子按1：1比例配合形成稳定二元体系配合物,其分子式为DyC15H8O7Cl2＆#183;6H2O。研究表明,在紫外光谱中,配合物的吸收波长分别红移了11nm和38nm;红外光谱显示槲皮素分子中1656.42 cm-1上的苯环骨架在槲皮素-Dy3＋配合物中消失,表明槲皮素羰基中的氧与Dy3＋发生了反应;在荧光光谱中,配合物在最大激发波长为253 nm及最大发射波长为582 nm时表现出强的荧光效应;在二元体系中加入表面活性剂（曲拉通X-100和Tween 20）形成三元配合物,当加入量为2.0 mL时,三元配合物的荧光强度分别是二元体系的荧光强度的1.5倍和2倍。     

基于合约的构件易测试性设计支撑工具的设计与实现

构件技术的新特点为构件测试带来挑战.合约式设计是一种重要的软件易测试性设计方法.基于合约的构件易测试性设计为构件测试提供了一种有效的手段.设计并实现了一种新的合约式设计工具(PKUJDBCT),为构件的易测试性设计提供有力的支撑,并为今后进一步研究基于合约的构件易测试性设计方法打下了良好的基础.     

The development of Bi Fe O3-based ceramics

The multiferroic properties of Bi Fe O3-based ceramics were improved through optimizing their sintering method and doping with certain rare earth elements in pure Bi Fe O3. Some methods, especially liquid-phase sintering method has largely decreased the densities of oxygen vacancies and Fe2in Bi Fe O3-based ceramics, and thus their resistivity became high enough to measure the saturated polarization and the large piezoelectric d33 coefficient under the high electric field of [150 k V/cm. Besides,multiferroic properties were improved through the rare earth elements’ doping in pure Bi Fe O3. Magnetization commonly increases with the proportional increase of Nd,La, Sm and Dy contents up to ＊30 %, while ferroelectric phase can transform to paraelectric phase at a certain proportion. An improved magnetoelectric coupling was often observed at ferroelectric phase with a relatively large proportion. Besides, an enhanced piezoelectric coefficient is expected in Bi Fe O3-based ceramics with morphotropic phase boundaries as they are already observed in thin epitaxial Bi Fe O3 films.     

Transmission and demodulation of multi-polarization-multiplexed signals

We propose the configuration of signal multiplexing with four polarization states and investigate its transmission performance over single-mode fiber links. Using coherent detection and digital signal processing, a demodulation scheme for four-polarization-multiplexed (4PM) system is presented. We discuss the impact of crosstalk from polarization mode dispersion and polarization beam splitter misalignment on the proposed 4PM system. Furthermore, the transmission distance could be doubled to ~50 km by employing feedback decision equalizers.     

Genome editing and animal models

Transgenic technology allows a gene of interest to be introduced into the genome of a laboratory animal, and provides an extremely powerful tool to dissect the molecular mechanisms of disease. Transgenic mouse models made by microinjection of DNA into zygotic pro- nuclei in particular have been widely used by the genetics community for 30 years. However, it remains a rather crude approach： injected sequences randomly insert in multiple copies as concatamers, they can be mutagenic, and they have variable or silenced expression depending on the site of integration, a phenomenon called position effects. As a result, multiple lines are required in order to confirm appropriate transgene expression. This can be partially overcome by flanking transgenes with insulator sequences to protect the transgene from the influence of the sur- rounding regulatory elements. Large （〈300 kb） BAC- based transgenic vectors have also been shown to be more resistant to position effects. However, animals carrying extra copies of fairly large regions of the genome could have unpredictable phenotypes. The most effective method used to control for position effects is to target transgene insertion to specific genomic loci, the so-called targeted transgenesis; for instance, the fast, site-specific transgenic technology TargattTM. The purpose of this review is to provide an overview on the current existing methods for making targeted transgenic mouse models.     

Ion flux dropout observed near dipolarization front

An ion flux dropout near the dipolarization front （DF） at around XGSM =- 11 RE in the Earth＇ s plasma sheet was observed by Time History of Events and Macroscale Interaction during substorms （THEMIS） on March 31, 2009. The ion differential energy fluxes at energies from 450 eV to 150 keV measured by the ESA and SST instruments from THC began to decrease about 2 s before the detection of the DF and reached a local minimum 6 s later. Then, the ion fluxes gradually increased to form a dropout around the DF. The spatial extent of the dropout was about 4,000 km. For energies above 20 keV, the ion fluxes after the dropout are greater than those before it, contrary to the fluxes at energies below 20 keV. The associated ion density variation indicates that the ion flux dropout coincides with the ion density dropout. Taking advantage of multipoint observations, THD, THC, and THE detected the same DF consecutively. Only THC detected an obvious ion flux dropout; THD observed an indistinct one about 2 s before THC; no high-energy （E 〉 30 keV） ion flux dropout was observed by THE. Our study suggests that the ion flux dropout may evolve with the earthward-propagating DF, and its properties can depend on locations relative to the DF.